Integrated or External cip in place cleaning system
Komal manufactures stainless steel pilot scale to production scale Fermentor/Bioreactors which are customized as per the process needs. Biopharma vessels takes into accounts various critical parameters and control devices to make the process effective and efficient.
Vessels are suitable for the cultivation of microbial/animal culture – utilizing robust, industry-standard components of reputed makes for easy integration into any production facility.
Our process range is designed as per ASME/BPE/PED guidelines and with capacities ranging from 5 L to 200 KL and includes process vessels for
Media Preparation Vessels
Buffer Preparation Vessels
Harvest Vessels
Chromatography Loading Vessels
Refolding Vessels
Elution Vessels
CIP Vessels
Stability Study Vessels
During the process, the below-mentioned parameters are maintained based on set parameters
Temperature: Sterilization and Temperature control to be maintained at set
Pressure: pressure sensor at vessel top and back pressure control valve at vent line to control the vessel pressure and back pressure
Agitation: Motor with variable frequency drive controls the agitation speed
pH: pH is controlled by acid and alkali solution using peristaltic pumps that works based on feedback from the pH sensor.
Foam: Foam is controlled by antifoam solution using peristaltic pumps that work based on feedback from the pH sensor.
DO: Cascade mode DO control is agitation and aeration (1.5VVM) by enable/disable options
Level: Level is controlled by pulsing WFI valve that works based on feedback from the level sensor
After harvesting the batch, CIP is carried out through spray balls
Features
Leading industry components for automation, electronics, sensors, valves and gas mixing, among others, offer quality without compromise
