Komal Industries

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Bioreactors / Fermenters

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fermenters-bioreactors-product
Integrated or External cip in place cleaning system

Komal manufactures stainless steel pilot scale to production scale Fermenter/Bioreactors which are customized as per the process needs. Biopharma vessels takes into accounts various critical parameters and control devices to make the process effective and efficient.

Vessels are suitable for the cultivation of microbial/animal culture – utilizing robust, industry-standard components of reputed makes for easy integration into any production facility.
Our process range is designed as per ASME/BPE/PED guidelines and with capacities ranging from 5 L to 200 KL and includes process vessels for
  • Media Preparation Vessels
  • Buffer Preparation Vessels
  • Harvest Vessels
  • Chromatography Loading Vessels
  • Refolding Vessels
  • Elution Vessels
  • CIP Vessels
  • Stability Study Vessels
During the process, the below-mentioned parameters are maintained based on set parameters
  1. Temperature: Sterilization and Temperature control to be maintained at set.
  2. Pressure: pressure sensor at vessel top and back pressure control valve at vent line to control the vessel pressure and back pressure.
  3. Agitation: A motor with variable frequency drive controls the agitation speed.
  4. pH: pH is controlled by acid and alkali solution using peristaltic pumps that works based on feedback from the pH sensor.
  5. Foam: Foam is controlled by antifoam solution using peristaltic pumps that work based on feedback from the pH sensor.
  6. DO: Cascade mode DO control is agitation and aeration (1.5VVM) by enable/disable options.
  7. Level: Level is controlled by a pulsing WFI valve that works based on feedback from the level sensor.

After harvesting the batch, CIP is carried out through spray balls.

Features
  • Leading industry components for automation, electronics, sensors, valves, and gas mixing, among others, offer quality without compromise.
  • Piping module design eliminates casual operator contact.
  • Powerful SCADA software to simultaneously manage multiple bioreactors.
  • Fully automatic in-situ sterilization with integrated steam generator.
  • Integrated or external CIP in place cleaning system.
  • Modular design and interconnectivity with external devices give the possibility of individual solutions.
  • Customisation of the process as per client process requirements.
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